MiR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss.

ABSTRACT: Developing novel approaches to treat skeletal disorders requires an understanding of how critical molecular factors regulate osteoblast differentiation and bone remodeling. We have reported that (1) retinoic acid receptor-related orphan receptor beta (Rorβ) is upregulated in bone samples isolated from aged mice and humans in vivo; (2) Rorβ expression is inhibited during osteoblastic differentiation in vitro; and (3) genetic deletion of Rorβ in mice results in preservation of bone mass during aging. These data establish that Rorβ inhibits osteogenesis and that strict control of Rorβ expression is essential for bone homeostasis. Because microRNAs (miRNAs) are known to play important roles in the regulation of gene expression in bone, we explored whether a predicted subset of nine miRNAs regu

SUBMITTER: Aquino-Martinez R 

PROVIDER: S-EPMC6450079 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature