The Role of Oncolytic Viruses in the Treatment of Melanoma.

ABSTRACT:

Purpose of review

Oncolytic virotherapy is a new approach to the treatment of cancer and its success in the treatment of melanoma represents a breakthrough in cancer therapeutics. This paper provides a review of the current literature on the use of oncolytic viruses (OVs) in the treatment of melanoma.

Recent findings

Talimogene laherparepvec (T-VEC) is the first OV approved for the treatment of melanoma and presents new challenges as it enters the clinical setting. Several other OVs are at various stages of clinical and pre-clinical development for the treatment of melanoma. Reports from phase Ib-III clinical trials combining T-VEC with checkpoint blockade are encouraging and demonstrate potential added benefit of combination immunotherapy. OVs have recently emerged as a sta

SUBMITTER: Bayan CY 

PROVIDER: S-EPMC6450085 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature