Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research.

ABSTRACT: The adult liver of most vertebrates is predominantly comprised of hepatocytes. However, these cells must work in concert with biliary, stellate, vascular, and immune cells to accomplish the vast array of hepatic functions required for physiological homeostasis. Our understanding of liver development was accelerated as zebrafish emerged as an ideal vertebrate system to study embryogenesis. Through work in zebrafish and other models, it is now clear that the cells in the liver develop in a coordinated fashion during embryogenesis through a complex yet incompletely understood set of molecular guidelines. Zebrafish research has uncovered many key players that govern the acquisition of hepatic potential, cell fate, and plasticity. Although rare, some hepatobiliary diseases-especially biliary at

SUBMITTER: Wang S 

PROVIDER: S-EPMC6450094 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature