Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

ABSTRACT:

Importance

Catheter ablation is more effective than drug therapy in restoring sinus rhythm in patients with atrial fibrillation (AF), but its incremental effect on long-term quality of life (QOL) is uncertain.

Objective

To determine whether catheter ablation is more beneficial than conventional drug therapy for improving QOL in patients with AF.

Design, setting, and participants

An open-label randomized clinical trial of catheter ablation vs drug therapy in 2204 symptomatic patients with AF older than 65 years or 65 years or younger with at least 1 risk factor for stroke. Patients were enrolled from November 2009 to April 2016 from 126 centers in 10 countries. Follow-up ended in December 2017.

Interventions

Pulmonary vein isolation, with additional ablation pro

SUBMITTER: Mark DB 

PROVIDER: S-EPMC6450275 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature