Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study.

ABSTRACT:

Importance

Increasing evidence shows that physical activity is associated with reduced risk for depression, pointing to a potential modifiable target for prevention. However, the causality and direction of this association are not clear; physical activity may protect against depression, and/or depression may result in decreased physical activity.

Objective

To examine bidirectional relationships between physical activity and depression using a genetically informed method for assessing potential causal inference.

Design, setting, and participants

This 2-sample mendelian randomization (MR) used independent top genetic variants associated with 2 physical activity phenotypes-self-reported (n = 377 234) and objective accelerometer-based (n = 91 084)-and with major depressiv

SUBMITTER: Choi KW 

PROVIDER: S-EPMC6450288 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature