Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study.

ABSTRACT:

Importance

Deviation from normal adolescent brain development precedes manifestations of many major psychiatric symptoms. Such altered developmental trajectories in adolescents may be linked to genetic risk for psychopathology.

Objective

To identify genetic variants associated with adolescent brain structure and explore psychopathologic relevance of such associations.

Design, setting, and participants

Voxelwise genome-wide association study in a cohort of healthy adolescents aged 14 years and validation of the findings using 4 independent samples across the life span with allele-specific expression analysis of top hits. Group comparison of the identified gene-brain association among patients with schizophrenia, unaffected siblings, and healthy control individuals. Thi

SUBMITTER: Luo Q 

PROVIDER: S-EPMC6450291 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature