Interval estimators of relative potency in toxicology and radiation countermeasure studies: comparing methods and experimental designs.

ABSTRACT: The relative potency of one agent to another is commonly represented by the ratio of two quantal response parameters; for example, the LD₅₀ of animals receiving a treatment to the LD₅₀ of control animals, where LD₅₀ is the dose of toxin that is lethal to 50% of animals. Though others have considered interval estimators of LD₅₀, here, we extend Bayesian, bootstrap, likelihood ratio, Fieller's and Wald's methods to estimate intervals for relative potency in a parallel-line assay context. In addition to comparing their coverage probabilities, we also consider their power in two types of dose designs: one assigning treatment and control the same doses vs. one choosing doses for treatment and control to achieve same lethality targets. We explore these

SUBMITTER: Landes RD 

PROVIDER: S-EPMC6450382 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature