Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.

ABSTRACT: IMPACT STATEMENT:Cartilage particles derived from human induced pluripotent stem cells (hiPS-Carts) are one candidate source for transplants for treatment of articular cartilage damage. This study shows that hiPS-Carts integrate with each other in an in vitro model and analyzed the course of the integration. The integration starts at the perichondrium-like membrane at around 1 week and then progresses to the central cartilage within 4-8 weeks. The results indicate that FGF18 secreted from the perichondrium-like membrane accelerates the initial step of integration. The findings contribute to understanding how hiPS-Carts form repair tissue and provide clue to accelerate healing after transplantation.

SUBMITTER: Chen X 

PROVIDER: S-EPMC6450455 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature