The Precision HYpertenSIon Care (PHYSIC) study: a double-blind, randomized, repeated cross-over study.

ABSTRACT: High blood pressure is the leading risk factor for premature deaths and a major cost to societies worldwide. Effective blood pressure-lowering drugs are available, but patient adherence to them is low, likely partly due to side effects. To identify patient-specific differences in treatment effects, a repeated cross-over design, where the same treatment contrasts are repeated within each patient, is needed. Such designs have been surprisingly rarely used, given the current focus on precision medicine. The Precision HYpertenSIon Care (PHYSIC) study aims to investigate if there is a consistent between-person variation in blood pressure response to the common blood pressure-lowering drug classes of a clinically relevant magnitude, given the within-person variation in blood pressure. The study

SUBMITTER: Sundstrom J 

PROVIDER: S-EPMC6450492 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature