Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.

ABSTRACT: S-Adenosyl-L-methionine (AdoMet), the primary methyl donor in most biological methylation reactions, is produced from ATP and methionine in a multistep reaction catalyzed by AdoMet synthetase. The diversity of group-transfer reactions that involve AdoMet places this compound at a key crossroads in amino-acid, nucleic acid and lipid metabolism, and disruption of its synthesis has adverse consequences for all forms of life. The family of AdoMet synthetases is highly conserved, and structures of this enzyme have been determined from organisms ranging from bacteria to humans. Here, the structure of an AdoMet synthetase from the infectious parasite Cryptosporidium parvum has been determined as part of an effort to identify structural differences in this enzyme family that can guide the developm

SUBMITTER: Ohren J 

PROVIDER: S-EPMC6450524 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature