Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS).

Methods

Linkage disequilibrium score regression and Mendelian randomization were applied in a large-scale, data-driven manner to explore genetic correlations and causal relationships between >700 phenotypic traits and ALS. Exposures consisted of publicly available genome-wide association studies (GWASes) summary statistics from MR Base and LD-hub. The outcome data came from the recently published ALS GWAS involving 20,806 cases and 59,804 controls. Multivariate analyses, genetic risk profiling, and Bayesian colocalization analyses were also performed.

Results

We have shown, by linkage disequilibrium score regression, that ALS shares polygenic risk genetic factor

SUBMITTER: Bandres-Ciga S 

PROVIDER: S-EPMC6450729 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature