Stromal Gas6 promotes the progression of premalignant mammary cells.

ABSTRACT: Tumor progression is regulated by a complex interplay between neoplastic cells and the tumor microenvironment. Tumor-associated macrophages have been shown to promote breast cancer progression in advanced disease and more recently, in early stage cancers. However, little is known about the macrophage-derived factors that promote tumor progression in early stage lesions. Using a p53-null model of early stage mammary tumor progression, we found that Gas6 is highly expressed in pre-invasive lesions associated with increased infiltrating macrophages, as compared with those with few recruited macrophages. We show that F4/80⁺CD11b⁺ macrophages produce Gas6 in premalignant lesions in vivo, and that macrophage-derived Gas6 induces a tumor-like phenotype ex vivo. Using a 3-D c

SUBMITTER: Gomes AM 

PROVIDER: S-EPMC6450766 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature