Ontology highlight
ABSTRACT:
SUBMITTER: Sakaguchi M
PROVIDER: S-EPMC6450906 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190405 1
A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and FoxK2 are also downstream targets of insulin action, but that following insulin stimulation, they translocate from the cytoplasm to nucleus, reciprocal to the translocation of FoxO1. FoxK1/FoxK2 translocation to the nucleus is dependent on the Akt-m ...[more]