Development of an ex vivo respiratory pediatric model of bronchopulmonary dysplasia for aerosol deposition studies.

ABSTRACT: Ethical restrictions are limitations of in vivo inhalation studies, on humans and animal models. Thus, in vitro or ex vivo anatomical models offer an interesting alternative if limitations are clearly identified and if extrapolation to human is made with caution. This work aimed to develop an ex vivo infant-like respiratory model of bronchopulmonary dysplasia easy to use, reliable and relevant compared to in vivo infant data. This model is composed of a 3D-printed head connected to a sealed enclosure containing a leporine thorax. Physiological data and pleural-mimicking depressions were measured for chosen respiratory rates. Homogeneity of ventilation was assessed by ^81mkrypton scintigraphies. Regional radioaerosol deposition was quantified with ^99mtechnetium-diethyle

SUBMITTER: Montigaud Y 

PROVIDER: S-EPMC6450907 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature