Viscoelastic biomarker for differentiation of benign and malignant breast lesion in ultra- low frequency range.

ABSTRACT: Benign and malignant tumors differ in the viscoelastic properties of their cellular microenvironments and in their spatiotemporal response to very low frequency stimuli. These differences can introduce a unique viscoelastic biomarker in differentiation of benign and malignant tumors. This biomarker may reduce the number of unnecessary biopsies in breast patients. Although different methods have been developed so far for this purpose, none of them have focused on in vivo and in situ assessment of local viscoelastic properties in the ultra-low (sub-Hertz) frequency range. Here we introduce a new, noninvasive model-free method called Loss Angle Mapping (LAM). We assessed the performance results on 156 breast patients. The method was further improved by detection of out-of-plane motion using m

SUBMITTER: Nabavizadeh A 

PROVIDER: S-EPMC6450913 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature