Effect of genotype and age on cerebral [¹⁸F]FDG uptake varies between transgenic APP_Swe-PS1_dE9 and Tg2576 mouse models of Alzheimer's disease.

ABSTRACT: Back-translation of clinical imaging biomarkers of Alzheimer's disease (AD), such as alterations in cerebral glucose metabolism detected by [¹⁸F]FDG positron emission tomography (PET), would be valuable for preclinical studies evaluating new disease-modifying drugs for AD. However, previous confounding results have been difficult to interpret due to differences in mouse models and imaging protocols between studies. We used an equivalent study design and [¹⁸F]FDG µPET imaging protocol to compare changes in cerebral glucose metabolism in commercial transgenic APP_Swe-PS1_dE9 (n = 12), Tg2576 (n = 15), and wild-type mice (n = 15 and 9). Dynamic [¹⁸F]FDG scans were performed in young (6 months) and aged (12 or 17 months) mice and the results

SUBMITTER: Snellman A 

PROVIDER: S-EPMC6450965 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature