Evolution of folate biosynthesis and metabolism across algae and land plant lineages.

ABSTRACT: Tetrahydrofolate and its derivatives, commonly known as folates, are essential for almost all living organisms. Besides acting as one-carbon donors and acceptors in reactions producing various important biomolecules such as nucleic and amino acids, as well as pantothenate, they also supply one-carbon units for methylation reactions. Plants along with bacteria, yeast and fungi synthesize folates de novo and therefore constitute a very important dietary source of folates for animals. All the major steps of folate biosynthesis and metabolism have been identified but only few have been genetically characterized in a handful of model plant species. The possible differences in the folate pathway between various plant and algal species have never been explored. In this study we present a comprehe

SUBMITTER: Gorelova V 

PROVIDER: S-EPMC6451014 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature