The citrus flavanone hesperetin preferentially inhibits slow-inactivating currents of a long QT syndrome type 3 syndrome Na⁺ channel mutation.

ABSTRACT:

Background and purpose

The citrus flavanone hesperetin has been proposed for the treatment of several human pathologies, but its cardiovascular actions remain largely unexplored. Here, we evaluated the effect of hesperetin on cardiac electrical and contractile activities, on aortic contraction, on the wild-type voltage-gated Na_V 1.5 channel, and on a channel mutant (R1623Q) associated with lethal ventricular arrhythmias in the long QT syndrome type 3 (LQT3).

Experimental approach

We used cardiac surface ECG and contraction force recordings to evaluate the effects of hesperetin in rat isolated hearts and aortic rings. Whole-cell patch clamp was used to record Na_V 1.5 currents (I_Na ) in rat ventricular cardiomyocytes and in HEK293T cells expres

SUBMITTER: Alvarez-Collazo J 

PROVIDER: S-EPMC6451064 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature