Stability of urinary albumin and creatinine after 12 months storage at -20 °C and -80 °C.

ABSTRACT:

Background

Increasing albumin to creatinine ratio (ACR) within the normal range is a risk factor for cardiovascular disease in the general population. Clinical and epidemiological studies often store urine samples for long durations prior to ACR assessment. The stability of ACR at the lowest urinary albumin concentrations during prolonged storage has not been previously studied because routine clinical assays can't quantify very low concentrations of albumin.

Aim

To determine the stability of urinary albumin and creatinine over 12 months in samples stored at -20 °C and -80 °C using an assay which enables assessment of previously undetectable levels of albumin and to investigate if additives can be used to prevent urinary albumin degradation.

Method

ACR was measured in

SUBMITTER: Chapman DP 

PROVIDER: S-EPMC6451166 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature