Discovery of non-invasive biomarkers for the diagnosis of endometriosis.

ABSTRACT:

Background

Endometriosis is a common gynaecological disorder affecting 5-10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing patients to potentially serious complications, and is often delayed. Non-invasive biomarkers are urgently required to accelerate diagnosis and for triaging potential patients for surgery.

Methods

This retrospective case control biomarker discovery and validation study used quantitative 2D-difference gel electrophoresis and tandem mass tagging-liquid chromatography-tandem mass spectrometry for protein expression profiling of eutopic and ectopic endometrial tissue samples collected from 28 cases of endometriosis and 18 control patients undergoing surgery for inve

SUBMITTER: Irungu S 

PROVIDER: S-EPMC6451201 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature