Levels of circulating insulin cell-free DNA in women with polycystic ovary syndrome - a longitudinal cohort study.

ABSTRACT:

Background

Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances in PCOS women have not been identified. The abundance of circulating insulin gene promotor cell-free DNA (INS cfDNA) was shown to be valuable as a predictive biomarker of β-cell death in individuals with Type 1 diabetes (T1D) as well as with gestational diabetes. Since β-cell death is common to the development of T1D as well as in T2D, we aimed to investigate if insulin-coding DNA is more abundant in circulation of PCOS women (vs Controls) and if their levels change after 6 yr. follow-up as a potential measure to predict future T2D.

Methods

A cohort of 40 wo

SUBMITTER: Udesen PB 

PROVIDER: S-EPMC6451227 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature