Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia.

ABSTRACT:

Background

Based on genome-wide association studies, a single-nucleotide polymorphism in the NRGN gene (rs12807809) is considered associated with schizophrenia (SZ). Moreover, hippocampal dysfunction is associated with rs12807809. In addition, converging evidence suggests that hippocampal dysfunction is involved in SZ pathophysiology. However, the association among rs12807809, hippocampal dysfunction and SZ pathophysiology is unknown. Therefore, this study investigated the association between rs12807809 and hippocampal functional connectivity at rest in SZ.

Methods

In total, 158 participants were studied, including a C-carrier group carrying the non-risk C allele (29 SZ patients and 46 healthy controls) and a TT homozygous group carrying the risk T allele (30 SZ patients and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6451258 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature