De novo transcription of multiple Hox cluster genes takes place simultaneously in early Xenopus tropicalis embryos.

ABSTRACT: hox genes are found as clusters in the genome in most bilaterians. The order of genes in the cluster is supposed to be correlated with the site of expression along the anterior-posterior body axis and the timing of expression during development, and these correlations are called spatial and temporal collinearity, respectively. Here we studied the expression dynamics of all hox genes of the diploid species Xenopus tropicalis in four Hox clusters (A-D) by analyzing high-temporal-resolution RNA-seq databases and the results showed that temporal collinearity is not supported, which is consistent with our previous data from allotetraploid Xenopuslaevis Because the temporal collinearity hypothesis implicitly assumes the collinear order of gene activation, not mRNA accumulation, we determined for

SUBMITTER: Kondo M 

PROVIDER: S-EPMC6451350 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature