Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses.

ABSTRACT: Arboviruses that are transmitted to humans by mosquitoes represent one of the most important causes of febrile illness worldwide. In recent decades, we have witnessed a dramatic re-emergence of several mosquito-borne arboviruses, including dengue virus (DENV), West Nile virus (WNV), chikungunya virus (CHIKV) and Zika virus (ZIKV). DENV is currently the most common mosquito-borne arbovirus, with an estimated 390 million infections worldwide annually. Despite a global effort, no specific therapeutic strategies are available to combat the diseases caused by these viruses. Multiple cellular pathways modulate the outcome of infection by either promoting or hampering viral replication and/or pathogenesis, and autophagy appears to be one of them. Autophagy is a degradative pathway generally induc

SUBMITTER: Echavarria-Consuegra L 

PROVIDER: S-EPMC6451359 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature