Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.

ABSTRACT: Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with chemotherapy are incompletely understood. Here, we show that targeting tumour-associated macrophages by colony-stimulating factor-1 receptor (CSF-1R) blockade in the K14cre;Cdh1^F/F;Trp53^F/F transgenic mouse model for breast cancer stimulates intratumoural type I interferon (IFN) signalling, which enhances the anticancer efficacy of platinum-based chemotherapeutics. Notably, anti-CSF-1R treatment also increased intratumoural expression of type I IFN-stimulated genes in patients with cancer, confirming that CSF-1R blockade is a powerful strategy to trigger an intr

SUBMITTER: Salvagno C 

PROVIDER: S-EPMC6451630 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature