Cell death pathologies: targeting death pathways and the immune system for cancer therapy.

ABSTRACT: Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse conditions. Regulated cell death has historically been exclusively associated with classical apoptosis; however, increasing evidence indicates that several alternative mechanisms orchestrate multiple death pathways, such as ferroptosis, entosis, necroptosis and immunogenic cell death, each with distinct underlying molecular mechanisms. Although pharmacological targeting of cell death pathways has been the subject of intensive efforts in recent decades with a dominant focus on targeting apoptosis, the identification of these novel death pathways

SUBMITTER: Pentimalli F 

PROVIDER: S-EPMC6451632 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature