Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.

ABSTRACT:

Aims/hypothesis

Patients with autoimmune type 1 diabetes transplanted with pancreatic islets to their liver experience significant improvement in quality of life through better control of blood sugar and enhanced awareness of hypoglycaemia. However, long-term survival and efficacy of the intrahepatic islet transplant are limited owing to liver-specific complications, such as immediate blood-mediated immune reaction, hypoxia, a highly enzymatic and inflammatory environment and locally elevated levels of drugs including immunosuppressive agents, all of which are injurious to islets. This has spurred a search for new islet transplant sites and for innovative ways to achieve long-term graft survival and efficacy without life-long systemic immunosuppression and its complications.

Met

SUBMITTER: Abdulreda MH 

PROVIDER: S-EPMC6451664 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature