A Prospective Study of the Association between Physical Activity and Risk of Prostate Cancer Defined by Clinical Features and TMPRSS2:ERG.

ABSTRACT:

Background

Growing evidence shows that clinical and molecular subtypes of prostate cancer (PCa) have specific risk factors. Observational studies suggest that physical activity may lower the risk of aggressive PCa. To our knowledge, the association between physical activity and PCa defined by TMPRSS2:ERG has not been evaluated.

Objective

To prospectively examine the association between physical activity and risk of PCa defined by clinical features and TMPRSS2:ERG.

Design, setting, and participants

We studied 49160 men aged 40-75 yr in the Health Professionals Follow-up Study from 1986 to 2012. Data was collected at baseline and every 2 yr with >90% follow-up. Total and vigorous physical activity were measured in metabolic equivalent of task (MET)-h/wk.

Outcome meas

SUBMITTER: Pernar CH 

PROVIDER: S-EPMC6451672 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature