Biomimetic Micromotor Enables Active Delivery of Antigens for Oral Vaccination.

ABSTRACT: Vaccination represents one of the most effective means of preventing infectious disease. In order to maximize the utility of vaccines, highly potent formulations that are easy to administer and promote high patient compliance are desired. In the present work, a biomimetic self-propelling micromotor formulation is developed for use as an oral antivirulence vaccine. The propulsion is provided by a magnesium-based core, and a biomimetic cell membrane coating is used to detain and neutralize a toxic antigenic payload. The resulting motor toxoids leverage their propulsion properties in order to more effectively elicit mucosal immune responses. After demonstrating the successful fabrication of the motor toxoids, their uptake properties are shown in vitro. When delivered to mice via an oral route

SUBMITTER: Wei X 

PROVIDER: S-EPMC6451690 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature