Fasting glucose and insulin resistance trajectories during young adulthood and mid-life cardiac structure and function.

ABSTRACT:

Aims

We assessed whether fasting glucose (FG) and insulin resistance (IR) trajectories during young adulthood are associated with changes in cardiac structure and function.

Methods

We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (baseline: 1985-1986). Echocardiography was performed after 25 (Y25) and 30 years of follow-up. Group-based modeling was used to determine 25-year trajectories in FG and IR. We assessed differences at Y25 and 5-year longitudinal change in cardiac structure and function after adjustment for demographics, cumulative exposure to traditional cardiovascular risk factors, and baseline FG or IR.

Results

We identified five FG trajectory groups among 2414 individuals and three IR trajectory groups among 2358 indivi

SUBMITTER: Bancks MP 

PROVIDER: S-EPMC6451883 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature