Loss of an IgG plasma cell checkpoint in patients with lupus.

ABSTRACT:

Background

IgG antinuclear antibodies (ANAs) are a feature of several autoimmune diseases. These antibodies arise through defects in central or peripheral tolerance checkpoints. The specific checkpoints breached in patients with autoimmune disease are not fully understood.

Objectives

We sought to study whether autoreactive plasma cells in lupus models and patients with systemic lupus erythematosus (SLE) arise as a consequence of defective antigen-specific selection or a global enhancement of IgG plasma cell differentiation.

Methods

We optimized and validated a novel technique to detect naturally occurring ANA⁺ B cells and plasma cells.

Results

We observed a major checkpoint for generation of ANA⁺ IgG⁺ plasma cells in both nonaut

SUBMITTER: Suurmond J 

PROVIDER: S-EPMC6451885 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature