Transmission ecology of canine parvovirus in a multi-host, multi-pathogen system.

ABSTRACT: Understanding multi-host pathogen maintenance and transmission dynamics is critical for disease control. However, transmission dynamics remain enigmatic largely because they are difficult to observe directly, particularly in wildlife. Here, we investigate the transmission dynamics of canine parvovirus (CPV) using state-space modelling of 20 years of CPV serology data from domestic dogs and African lions in the Serengeti ecosystem. We show that, although vaccination reduces the probability of infection in dogs, and despite indirect enhancement of population seropositivity as a result of vaccine shedding, the vaccination coverage achieved has been insufficient to prevent CPV from becoming widespread. CPV is maintained by the dog population and has become endemic with approximately 3.5-year c

SUBMITTER: Behdenna A 

PROVIDER: S-EPMC6452066 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature