G1 is the major APOL1 risk allele for hypertension-attributed nephropathy in Central Africa.

ABSTRACT:

Background

Sub-Saharan Africans exhibit a higher frequency of chronic kidney disease (CKD) than other populations. In this study, we sought to determine the frequency of apolipoprotein L1 (APOL1) genotypes in hypertension-attributed CKD in Kinshasa, Democratic Republic of the Congo.

Methods

We performed a case-control study identifying 162 subjects: 79 with hypertension-attributed CKD and 83 controls living in Kinshasa who were genotyped for APOL1 risk variants between July 2013 and November 2016. We selected control subjects from the general population and matched them with the cases according to age. Logistic regression analysis was used to examine the relationship between APOL1 high-risk genotypes and CKD.

Results

The frequencies of the APOL

SUBMITTER: Sumaili EK 

PROVIDER: S-EPMC6452203 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature