Viral Load Dynamics and Clinical Disease Severity in Infants With Respiratory Syncytial Virus Infection.

ABSTRACT:

Background

The association between respiratory syncytial virus (RSV) loads and clinical outcomes in children remains to be defined. In most studies, viral loads (VL) were evaluated in hospitalized children and at a single time-point. We investigated the relationship between VLs and disease severity in both outpatients and inpatients with RSV infection.

Methods

We enrolled previously healthy children with RSV infection. Disease severity was defined by level of care (outpatients vs ward vs pediatric intensive care unit [PICU]), and a clinical disease severity score (CDSS). Nasopharyngeal VLs by polymerase chain reaction and CDSS were measured at enrollment and daily in inpatients. VL decay according to disease severity was analyzed using linear mixed modeling.

Results

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SUBMITTER: Garcia-Maurino C 

PROVIDER: S-EPMC6452299 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature