Genetic Evidence of Focal Plasmodium falciparum Transmission in a Pre-elimination Setting in Southern Province, Zambia.

ABSTRACT:

Background

Southern Province, Zambia has experienced a dramatic decline in Plasmodium falciparum malaria transmission in the past decade and is targeted for elimination. Zambia's National Malaria Elimination Program recommends reactive case detection (RCD) within 140 m of index households to enhance surveillance and eliminate remaining transmission foci.

Methods

To evaluate whether RCD captures local transmission, we genotyped 26 microsatellites from 106 samples collected from index (n = 27) and secondary (n = 79) cases detected through RCD in the Macha Hospital catchment area between January 2015 and April 2016.

Results

Participants from the same RCD event harbored more genetically related parasites than those from different RCD events, suggesting that RCD captures,

SUBMITTER: Pringle JC 

PROVIDER: S-EPMC6452320 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature