Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum.

ABSTRACT: The primate cerebrum is characterized by a large expansion of cortical surface area, the formation of convolutions, and extraordinarily voluminous subcortical white matter. It was recently proposed that this expansion is primarily driven by increased production of superficial neurons in the dramatically enlarged outer subventricular zone (oSVZ). Here, we examined the development of the parietal cerebrum in macaque monkey and found that, indeed, the oSVZ initially adds neurons to the superficial layers II and III, increasing their thickness. However, as the oSVZ grows in size, its output changes to production of astrocytes and oligodendrocytes, which in primates outnumber cerebral neurons by a factor of three. After the completion of neurogenesis around embryonic day (E) 90, when the cerebr

SUBMITTER: Rash BG 

PROVIDER: S-EPMC6452694 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature