Elevated signature of a gene module coexpressed with CDC20 marks genomic instability in glioma.

ABSTRACT: Genomic instability (GI) drives tumor heterogeneity and promotes tumor progression and therapy resistance. However, causative factors underlying GI and means for clinical detection of GI in glioma are inadequately identified. We describe here that elevated expression of a gene module coexpressed with CDC20 (CDC20-M), the activator of the anaphase-promoting complex in the cell cycle, marks GI in glioma. The CDC20-M, containing 139 members involved in cell proliferation, DNA damage response, and chromosome segregation, was found to be consistently coexpressed in glioma transcriptomes. The coexpression of these genes was conserved across multiple species and organ systems, particularly in human neural stem and progenitor cells. CDC20-M expression was not correlated with the morphological subt

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6452696 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature