Biomaterials-aided mandibular reconstruction using in vivo bioreactors.

ABSTRACT: Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves suitable for their own specific anatomical pathology. The in vivo bioreactor strategy facilitates the generation of large autologous vascularized bony tissue of customized geometry without the addition of exogenous growth factors or cells. To translate this technology, we investigated its success in reconstructing a mandibular defect of physiologically relevant size in sheep. We fabricated and implanted 3D-printed in vivo bioreactors against rib periosteum and utilized biomat

SUBMITTER: Tatara AM 

PROVIDER: S-EPMC6452741 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature