Genetic polymorphisms in Sox17 associated with intracranial aneurysm in Chinese Han people: a genotype-phenotype study.

ABSTRACT:

Purpose

Genetic factors play a vital role in intracranial aneurysm (IA) onset and development. Studying the relationship between IA and the Sox17 polymorphisms in diverse populations is essential for establishing credibility.

Patients and methods

We collected blood samples derived from a total of 596 sporadic IA patients and 600 individual controls in several medical institutes in China. We used the Sequenom MassArray system for single nucleotide polymorphisms (SNPs) genotyping after DNA extraction. The SNPs data was tested and analyzed in PLINK (version 1.9). Multiple-testing was performed in PLINK to make the statistics more rigorous and accurate.

Results

We found that the allelic G of rs1072737 (OR=1.303, genomic-control corrected P-value =0.001032) i

SUBMITTER: Li M 

PROVIDER: S-EPMC6452799 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature