Association of polymorphisms in MALAT1 with the risk of esophageal squamous cell carcinoma in a Chinese population.

ABSTRACT:

Objective

The main aim of this study was to investigate the association of polymorphisms in long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) with the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population.

Methods

A total of 245 ESCC patients and 490 gender- and age-matched cancer-free controls were genotyped for four tag single nucleotide polymorphisms (SNPs) of MALAT1 (rs3200401 C > T, rs1122709 C > G, rs664589 C > G, and rs619586 A > G). Statistical analyses including chi-squared test and logistic regression were performed to identify the association between the tag SNPs and risk of ESCC, and false discovery rate (FDR) <25% was applied to adjust for multiple comparisons.

Results

We found that rs3200401 C > T pol

SUBMITTER: Qu Y 

PROVIDER: S-EPMC6452823 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature