Mycobacteriophage ZoeJ: A broad host-range close relative of mycobacteriophage TM4.

ABSTRACT: A collection of over 1600 sequenced bacteriophages isolated on a single host strain, Mycobacterium smegmatis mc²155, can be grouped into over two dozen types that have little or no nucleotide sequence similarity to each other. One group, Cluster K, can be divided into several subclusters, and the well-characterized and much exploited phage TM4 lies in Subcluster K2. Many of the Cluster K phages have broad host ranges and infect both fast- and slow-growing mycobacterial strains. Here we describe phage ZoeJ, a new Subcluster K2 member, which infects a broad spectrum of mycobacterial hosts including M. smegmatis, Mycobacterium tuberculosis, and Mycobacterium avium. ZoeJ has extensive sequence similarity to TM4, and comparative analysis reveals the precise deletion conferring the ly

SUBMITTER: Dedrick RM 

PROVIDER: S-EPMC6452893 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature