A host gene expression approach for identifying triggers of asthma exacerbations.

ABSTRACT:

Rationale

Asthma exacerbations often occur due to infectious triggers, but determining whether infection is present and whether it is bacterial or viral remains clinically challenging. A diagnostic strategy that clarifies these uncertainties could enable personalized asthma treatment and mitigate antibiotic overuse.

Objectives

To explore the performance of validated peripheral blood gene expression signatures in discriminating bacterial, viral, and noninfectious triggers in subjects with asthma exacerbations.

Methods

Subjects with suspected asthma exacerbations of various etiologies were retrospectively selected for peripheral blood gene expression analysis from a pool of subjects previously enrolled in emergency departments with acute respiratory illness. RT-PCR quan

SUBMITTER: Lydon EC 

PROVIDER: S-EPMC6453459 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature