Determinants for progression from asymptomatic infection to symptomatic visceral leishmaniasis: A cohort study.

ABSTRACT:

Background

Asymptomatic Leishmania donovani infections outnumber clinical presentations, however the predictors for development of active disease are not well known. We aimed to identify serological, immunological and genetic markers for progression from L. donovani infection to clinical Visceral Leishmaniasis (VL).

Methods

We enrolled all residents >2 years of age in 27 VL endemic villages in Bihar (India). Blood samples collected on filter paper on two occasions 6-12 months apart, were tested for antibodies against L. donovani with rK39-ELISA and DAT. Sero converters, (negative for both tests in the first round but positive on either of the two during the second round) and controls (negative on both tests on both occasions) were followed for three years. At the start of fo

SUBMITTER: Chakravarty J 

PROVIDER: S-EPMC6453476 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature