The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy.

ABSTRACT: Adoptive T cell therapy is a form of cellular therapy that utilizes human immune cells, often empowered by the expression of recombinant proteins, to attack selected targets present on tumor or infected cells. T cell-based immunotherapy has been progressing over the past several decades, and reached a milestone with the recent US Food and Drug Administration (FDA) approval of chimeric antigen receptor T cell therapy for relapsed and refractory leukemia and lymphoma. Although most studies have used viral vectors, a growing number of researchers have come to appreciate in vitro-transcribed (IVT) mRNA for the development, testing, and application of T cell-based immunotherapeutics. IVT mRNA offers inherent safety features, highly efficient recombinant protein translation, and the ability to c

SUBMITTER: Foster JB 

PROVIDER: S-EPMC6453504 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature