MRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases.

ABSTRACT: In the last two decades, there has been growing interest in mRNA-based technology for the development of prophylactic vaccines against infectious diseases. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Potent, long-lasting, and safe immune responses observed in animal models, as well as encouraging data from early human clinical trials, make mRNA-based vaccination an attractive alternative to conventional vaccine approaches. Thanks to these data, together with the potential for generic, low-cost manufacturing processes and the completely synthetic nature, the prospects for mRNA vaccines are very promising. In addition, mRNA vaccines have the potential to streamline vaccine discovery a

SUBMITTER: Maruggi G 

PROVIDER: S-EPMC6453507 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature