Basal ganglia impairments in autism spectrum disorder are related to abnormal signal gating to prefrontal cortex.

ABSTRACT: Research on the biological basis of autism spectrum disorder has yielded a list of brain abnormalities that are arguably as diverse as the set of behavioral symptoms that characterize the disorder. Among these are patterns of abnormal cortical connectivity and abnormal basal ganglia development. In attempts to integrate the existing literature, the current paper tests the hypothesis that impairments in the basal ganglia's function to flexibly select and route task-relevant neural signals to the prefrontal cortex underpins patterns of abnormal synchronization between the prefrontal cortex and other cortical processing centers observed in individuals with autism spectrum disorder (ASD). We tested this hypothesis using a Dynamic Causal Modeling analysis of neuroimaging data collected from 16

SUBMITTER: Prat CS 

PROVIDER: S-EPMC6453580 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature