Upregulation of SIRT1 gene in gastric adenocarcinoma.

ABSTRACT:

Background/aims

SIRT1 gene overexpression is reportedly associated with cancer development, via the triggering of DNA repair impairment, and cell proliferation. The study aimed to investigate SIRT1 expression in patients with gastric cancer and its correlations with the clinical and pathological characteristics of the disease.

Materials and methods

All patients (64 patients) who underwent gastric biopsy and were diagnosed with gastric adenocarcinoma and signet ring cell carcinoma between January 2011 and December 2013 were enrolled in the study, and patients with benign gastric biopsy were enrolled in the control group (34 patients). The previously prepared gastric tissues were collected from the pathology department, and SIRT1 gene expressions were evaluated in the gastric

SUBMITTER: Ozcan O 

PROVIDER: S-EPMC6453656 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature