Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy.

ABSTRACT: In humans, circulating levels of the hormone melatonin and the initiation of spontaneous labor are both higher at night than during the day. Since activation of uterine melatonin receptors can stimulate human in vitro uterine contractions and these receptors are only expressed on the uterine tissue of women in labor, we hypothesized that circulating melatonin concentrations would affect uterine contractions in vivo. We evaluated the impact of light-induced modulation of melatonin secretion on uterine contractions in women during late third trimester (~36-39 weeks) of pregnancy in two inpatient protocols. We found a significant (P < 0.05) positive linear association between circulating melatonin concentrations and the number of uterine contractions under both protocols. On average, uterine

SUBMITTER: Rahman SA 

PROVIDER: S-EPMC6453747 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature