A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves.

ABSTRACT: The existence of axons extending from one retina to the other has been reported during perinatal development in different vertebrates. However, it has been thought that these axons are either a labeling artifact or misprojections. Here, we show unequivocally that a small subset of retinal ganglion cells (RGCs) project to the opposite retina and that the guidance receptor Unc5c, expressed in the retinal region where the retinal-retinal (R-R) RGCs are located, is necessary and sufficient to guide axons to the opposite retina. In addition, Netrin1, an Unc5c ligand, is expressed in the ventral diencephalon in a pattern that is consistent with impeding the growth of Unc5c-positive retinal axons into the brain. We also have generated a mathematical model to explore the formation of retinotopic m

SUBMITTER: Murcia-Belmonte V 

PROVIDER: S-EPMC6453780 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature