Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function.

ABSTRACT:

Background & aims

Renal clearance is the major elimination pathway for sofosbuvir (SOF). We assessed the safety and efficacy of SOF-containing regimens in patients with varying baseline estimated glomerular filtration rate (eGFR).

Methods

HCV-TARGET database is a multicentre, longitudinal 'real-world' treatment cohort.

Results

A total of 1789 patients [genotypes 1 (72%), 2 (17%) 3 (9%), 4-6 (2%)] had baseline eGFR determination: 73 with eGFR≤45 (18 with eGFR≤30, 5 on dialysis) were compared to 1716 with eGFR>45 ml/min/1.73 m(2) . Patients with baseline eGFR≤45 vs. >45 differed in being female (55% vs. 36%), age ≥65 years (24% vs. 16%), Black race (22% vs. 12%), having cirrhosis with decompensation (73% vs. 24%) and being post-transplant (49% vs. 10%), all P < 0.05. Al

SUBMITTER: Saxena V 

PROVIDER: S-EPMC6453817 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature